Trans-Cevimeline (hydrochloride)

• Description :

  Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1].

• Product Name Alternative :

  AF102A (hydrochloride)

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H332-H351-H361

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/trans-cevimeline-hydrochloride.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H]1SC[C@@]2(CN3CCC2CC3)O1.[H]Cl

• Molecular Formula :

  C10H18ClNOS

• Molecular Weight :

  235.77

• Precautions :

  P261-P264-P270-P271-P280-P304+P340-P330-P405-P501

• References & Citations :

  [1]Fisher A, et al. (+-) -cis-2-methyl-spiro (1,3-oxathiolane-5,3') quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther. 1991;257 (1) :392-403.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAChR1

• CAS Number :

  [107220-29-1]