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Propanidid

CAT: 0804-HY-116457-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116457-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABAA) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure[1][2].
CAS Number
1421-14-3
Product Name Alternative
Sombrevin; Fabantol
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/propanidid.html
Purity
98.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=C(C(OC)=C1)OCC(N(CC)CC)=O)OCCC
Molecular Formula
C18H27NO5
Molecular Weight
337.41
References & Citations
[1]Cenani A, et al. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4- (2-[Diethylamino]-2-Oxoethoxy) -3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019;103 (1-2) :10-16.|[2]Orko R. Anaesthesia for cardioversion: a comparison of diazepam, thiopentone and propanidid. Br J Anaesth. 1976 Mar;48 (3) :257-62.|[3]Lazareva NA, et al. The effect of sombrevin on the orientation adjustment of the visual cortex neurons in the cat. Neirofiziologiia. 1989;21 (6) :812-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Propanidid

Propanidid is a member of methoxybenzenes.

CAS Number1421-14-3
PubChem CID15004
IUPAC Namepropyl 2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetate
Molecular FormulaC18H27NO5
Molecular Weight337.4
XLogP2.8
Topological Polar Surface Area65.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count24
Formal Charge0
Complexity384
SMILES
CCCOC(=O)CC1=CC(=C(C=C1)OCC(=O)N(CC)CC)OC
InChI
InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3
InChIKey
KEJXLQUPYHWCNM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Propanidid
CAS: 1421-14-3
CID: 15004
Formula: C18H27NO5
MW: 337.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.4
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass337.18892296
Monoisotopic Mass337.18892296
Topological Polar Surface Area65.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity384
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5783670Propanidid

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