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4α-Phorbol 12,13-didecanoate

CAT: 0804-HY-116291Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116291Size:1 mg
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Description
4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca2+ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) [1][2][3][4].
CAS Number
27536-56-7
Product Name Alternative
4αPDD
UNSPSC
12352211
Hazard Statement
H300+H310+H330, H314, H317, H334, H351
Target
CHIKV; TRP Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4α-phorbol-12-13-didecanoate.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Molecular Formula
C40H64O8
Molecular Weight
672.93
Precautions
H300+H310+H330, H314, H317, H334, H351
References & Citations
[1]Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290 (6) :R1736-41.|[2]Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323 (1) :227-35. |[3]Alexander R, et al. 4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4. Br J Pharmacol. 2013 Feb;168 (3) :761-72.|[4]Nothias-Scaglia LF, et al. Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication. J Nat Prod. 2015 Jun 26;78 (6) :1277-83.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4

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