Aldophosphamide

• UNSPSC Description:

  Aldophosphamide (NSC 254) is a cyclophosphamide metabolite. Aldophosphamide is cleaved intracellularly to phosphoramide mustard, an active metabolite with direct cytotoxicity, and acrolein. Aldophosphamide has potential for cancer research[1].

• Target Antigen:

  Drug Metabolite; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/aldophosphamide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=CCCOP(N)(N(CCCl)CCCl)=O

• Molecular Weight:

  277.09

• References & Citations:

  [1]Fenselau C, et al. Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans. Cancer Res. 1977 Aug;37(8 Pt 1):2538-43.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  35144-64-0