MRTX-1257-d6

• Description :

  MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436) . MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1][2].

• CAS Number :

  [2639608-44-7]

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])N(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(CN(C5=CC=CC6=C5C(C([2H])([2H])[2H])=CC=C6)CC4)=N2

• Molecular Formula :

  C33H33D6N7O2

• Molecular Weight :

  571.75

• References & Citations :

  [1]Matthew et al. Structure-Based Drug Discovery of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-220.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported