Lycopodine

CAT: 0804-HY-114372Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-114372Size:1 Each
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Description
Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity[1]. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation[2].
CAS Number
[466-61-5]
UNSPSC
12352005
Target
Apoptosis; Caspase; Lipoxygenase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lycopodine.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@]2([H])[C@]34[C@@](CCCN4CCC2)([H])[C@](C[C@@H](C)C3)([H])C1
Molecular Formula
C16H25NO
Molecular Weight
247.38
References & Citations
[1]Bishayee K, et al. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. Eur J Pharmacol. 2013 Jan 5;698 (1-3) :110-21.|[2]Mandal SK, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol. 2010 Jan 25;626 (2-3) :115-22.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-LOX; Caspase 3

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