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3-Methylglutaric acid-d4

CAT: 0804-HY-113410SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113410SSize:1 mg
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Description
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration[1][2][3][4][5].
CAS Number
1219798-68-1
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Isotope-Labeled Compounds; Mitochondrial Metabolism; Na+/K+ ATPase; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC(C([2H])([2H])C(C)C([2H])([2H])C(O)=O)=O
Molecular Formula
C6H6D4O4
Molecular Weight
150.17
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ribeiro CA, et al. Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+, K+-ATPase activity probably through oxidative damage in brain cortex of young rats. Int J Dev Neurosci. 2011 Feb;29 (1) :1-7.|[3]da Rosa-Junior NT, et al. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver. Biochimie. 2020 Apr-May;171-172:187-196.|[4]da Rosa-Junior NT, et al. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats. Neurotox Res. 2019 May;35 (4) :809-822.|[5]Colín-González AL, et al. Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms. Neurochem Res. 2016 Oct;41 (10) :2619-2626.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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