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3-Methylglutaric acid (Standard)

CAT: 0804-HY-113410R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113410R-01Size:25 mg
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Description
3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid. This product is intended for research and analytical applications. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration[1][2][3][4].
CAS Number
626-51-7
UNSPSC
12352211
Target
Mitochondrial Metabolism; Na+/K+ ATPase; Reactive Oxygen Species (ROS) ; Reference Standards
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=C(O)CC(C)CC(O)=O
Molecular Formula
C6H10O4
Molecular Weight
146.14
References & Citations
[1]Ribeiro CA, et al. Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+, K+-ATPase activity probably through oxidative damage in brain cortex of young rats. Int J Dev Neurosci. 2011 Feb;29 (1) :1-7.|[2]da Rosa-Junior NT, et al. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver. Biochimie. 2020 Apr-May;171-172:187-196.|[3]da Rosa-Junior NT, et al. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats. Neurotox Res. 2019 May;35 (4) :809-822.|[4]Colín-González AL, et al. Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms. Neurochem Res. 2016 Oct;41 (10) :2619-2626.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

3-Methylglutaric acid

3-methylglutaric acid is an alpha,-dicarboxylic acid that is glutaric acid substituted at position 3 by a methyl group. It has a role as a metabolite. It is functionally related to a glutaric acid.

CAS Number626-51-7
PubChem CID12284
IUPAC Name3-methylpentanedioic acid
Molecular FormulaC6H10O4
Molecular Weight146.14
XLogP0.1
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count10
Formal Charge0
Complexity125
SMILES
CC(CC(=O)O)CC(=O)O
InChI
InChI=1S/C6H10O4/c1-4(2-5(7)8)3-6(9)10/h4H,2-3H2,1H3,(H,7,8)(H,9,10)
InChIKey
XJMMNTGIMDZPMU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Methylglutaric acid
CAS: 626-51-7
CID: 12284
Formula: C6H10O4
MW: 146.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight146.14
XLogP30.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass146.05790880
Monoisotopic Mass146.05790880
Topological Polar Surface Area74.6 Ų
Heavy Atom Count10
Formal Charge0
Complexity125
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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