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12S-HHT

CAT: 0804-HY-113330Size: 25 μg (356.6 μM x 250 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-113330Size:25 μg (356.6 μM x 250 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12S-HHT (12 (S) -HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX) -mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].
CAS Number
54397-84-1
Product Name Alternative
12 (S) -HHTrE
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12s-hht.html
Concentration
356.6 μM * 250 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O
Molecular Formula
C17H28O3
Molecular Weight
280.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36.|[2]Lee JW, et al. 12 (S) -Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44 (6) :378-386.|[3]Okuno T, et al. Metabolism and biological functions of 12 (S) -hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021;152:106502.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; LTB4

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