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DC41

CAT: 0804-HY-112901Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112901Size:1 Each
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Description
DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].
CAS Number
1354787-69-1
UNSPSC
12352203
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dc41.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=CC2=C1C=CC(NC(CCC(C)(S)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Molecular Formula
C37H34ClN5O4S
Molecular Weight
680.21
References & Citations
[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55 (2) :766-82.|[2]Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66 (6) :3214-21.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins

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