Sparfosic acid

• Description:

  Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3].

• UNSPSC:

  12352211

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sparfosic-acid.html

• Purity:

  99.33

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  O=C(O)C[C@@H](C(O)=O)NC(CP(O)(O)=O)=O

• Molecular Formula:

  C6H10NO8P

• Molecular Weight:

  255.12

• References & Citations:

  [1]Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47 (2) :782-90.|[2]Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid.|[3]Johnson RK, et al. Antitumor activity of N- (phosphonacetyl) -L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. Cancer Res. 1976;36 (8) :2720-2725.|[4]Wadler S, et al. Phase II trial of N- (phosphonacetyl) -L-aspartate (PALA), 5-fluorouracil and recombinant interferon-alpha-2b in patients with advanced gastric carcinoma. Eur J Cancer. 1996;32A (7) :1254-1256.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Nat Commun. 2024 Feb 16;15 (1) :1442.|Res Sq. 2025 Sep 14.|bioRxiv. 2023 Aug 3.|Nat Metab. 2025 Nov 13.

• CAS Number:

  [51321-79-0]