GDC0575 (hydrochloride)
CAT:
804-HY-112167B
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GDC0575 (hydrochloride)
- CAS Number: 1196504-54-7
- UNSPSC Description: GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research[1].
- Target Antigen: Checkpoint Kinase (Chk)
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Applications: COVID-19-anti-virus
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/gdc0575-hydrochloride.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.Cl
- Molecular Weight: 414.73
- References & Citations: [1]Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Mar 13. |[2] Laroche-Clary A, et al. CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. Ann Oncol. 2018 Apr 1;29(4):1023-1029.|[3] Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8(1):1679.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 1