ZEN-3411

• Description:

  ZEN-3411 is a BET inhibitor with IC50s of 0.05, 0.05 and 0.06 μM for BRD4 (BD1), BRD4 (BD2) and BRD4 (BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/zen-3411.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CC(C2=C(C)ON=C2C)=CC3=C1N=CN3CC4=CC=C(C5OC5)C=C4

• Molecular Formula:

  C21H20N4O2

• Molecular Weight:

  360.41

• References & Citations:

  [1]Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61 (18) :8202-8211.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BRD4

• CAS Number:

  [1952264-36-6]