Imatinib carbaldehyde

• Description:

  Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].

• Product Name Alternative:

  CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1

• UNSPSC:

  12352005

• Target:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-abl-binding-moiety-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(NC(C2=CC=C(CN3CCN(C=O)CC3)C=C2)=O)C=C1NC4=NC=CC(C5=CC=CN=C5)=N4

• Molecular Formula:

  C29H29N7O2

• Molecular Weight:

  507.59

• References & Citations:

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1436868-85-7]