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Imatinib-d4

CAT: 0804-HY-15463S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15463S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imatinib-d4 (STI571-d4) is a deuterium labeled Imatinib (STI571) . Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].
CAS Number
1134803-16-9
Product Name Alternative
STI571 D4; CGP-57148B D4
UNSPSC
12352005
Hazard Statement
H361
Target
Autophagy; Bcr-Abl; c-Kit; PDGFR; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.86
Solubility
10 mM in DMSO|DMSO : 12.5mg/mL (ultrasonic) |H2O : 10mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=C([2H])C([2H])=C(CN5CCN(C)CC5)C([2H])=C4[2H]
Molecular Formula
C29H27D4N7O
Molecular Weight
497.63
Precautions
H361
References & Citations
[1]Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1;96 (3) :925-32.|[2]Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13 (11) :3363-9.|[3]Coleman CM, et al, Frieman MB. Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. J Virol. 2016;90 (19) :8924‐8933. Published 2016 Sep 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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