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Macropa-NCS

CAT: 0804-HY-111605Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-111605Size:Inquire
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
[2146095-31-8]
UNSPSC Description
Macropa-NCS can be coupled with antibodies to form tumor-selective carrier molecules, which can be further combined with radionuclides as specific targeting cancer cell carriers, and is a linker-chelating agent in targeted alpha research (TAT)[1].
Target Antigen
ADC Linker; Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Macropa-NCS.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(CN2CCOCCOCCN(CC3=NC(C(O)=O)=CC=C3)CCOCCOCC2)=CC(N=C=S)=C1)O
Molecular Weight
589.66
References & Citations
[1]Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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