GSK317354A

CAT: 0804-HY-111239Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-111239Size:1 Each

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Description

GSK317354A is a ROCK and GRK inhibitor. GSK317354A can be used for heart failure and Parkinson’s disease research[1].

CAS Number

874119-13-8

UNSPSC

12352005

Target

G Protein-coupled Receptor Kinase (GRK) ; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsk317354a.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C2=CC=C(C(F)(F)F)N=C2)=NC1C3=CC=C(F)C=C3)NC4=CC5=C(NN=C5)C=C4

Molecular Formula

C25H18F4N6O

Molecular Weight

494.44

References & Citations

[1]Homan KT, et al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10 (1) :310-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ROCK

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