SPL-334

• Description:

  SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].

• UNSPSC:

  12352005

• Target:

  GSNOR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/spl-334.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=C(CSC2=NC3=C(C(N2CC4=CC=C(C(O)=O)C=C4)=O)SC=C3)C=CC=C1

• Molecular Formula:

  C22H15N3O3S2

• Molecular Weight:

  433.50

• References & Citations:

  [1]Ferrini ME, et, al. S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. PLoS One. 2013 Jul 25;8 (7) :e70351.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [688347-51-5]