SPL-410

• Description :

  SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM[1].

• UNSPSC :

  12352005

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/spl-410.html

• Concentration :

  10mM

• Purity :

  99.38

• Solubility :

  DMSO : 190 mg/mL (ultrasonic)

• Smiles :

  N[C@H]([C@@H](O)CN(C1CCC1)S(C2=CC=C(C(C)(C)C)C=C2)(=O)=O)C3=CC=C(OC(F)(F)F)C=C3

• Molecular Formula :

  C24H31F3N2O4S

• Molecular Weight :

  500.57

• References & Citations :

  [1]Velcicky J, et al. Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. ACS Med Chem Lett. 2019 May 23;10 (6) :887-892.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2351886-00-3]