SPL-410

• Description:

  SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM[1].

• UNSPSC:

  12352005

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/spl-410.html

• Concentration:

  10mM

• Purity:

  99.38

• Solubility:

  DMSO : 190 mg/mL (ultrasonic)

• Smiles:

  N[C@H]([C@@H](O)CN(C1CCC1)S(C2=CC=C(C(C)(C)C)C=C2)(=O)=O)C3=CC=C(OC(F)(F)F)C=C3

• Molecular Formula:

  C24H31F3N2O4S

• Molecular Weight:

  500.57

• References & Citations:

  [1]Velcicky J, et al. Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. ACS Med Chem Lett. 2019 May 23;10 (6) :887-892.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2351886-00-3]