Vatalanib (succinate)

• Description :

  Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1].

• Product Name Alternative :

  PTK787 (succinate) ; ZK-222584 (succinate) ; CGP-79787 (succinate)

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  VEGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/vatalanib-succinate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC(C=C1)=CC=C1NC2=C3C(C=CC=C3)=C(CC4=CC=NC=C4)N=N2.OC(CCC(O)=O)=O

• Molecular Formula :

  C24H21ClN4O4

• Molecular Weight :

  464.90

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]J M Wood, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60 (8) :2178-89.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

• CAS Number :

  [212142-18-2]