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Topiramate D12

CAT: 0804-HY-110234Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110234Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].
CAS Number
1279037-95-4
Product Name Alternative
McN 4853 D12 ; RWJ 17021 D12
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; Carbonic Anhydrase; GABA Receptor; iGluR; Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.90
Solubility
10 mM in DMSO
Smiles
NS(OC[C@]12[C@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O2)([H])[C@@]3([H])[C@@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O3)([H])CO1)(=O)=O
Molecular Formula
C12H9D12NO8S
Molecular Weight
351.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67 (15) :2231-56.|[2]Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115 (1) :53-7.|[3]Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46 (8) :1097-104.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
AMPA Receptor; Kainate Receptor

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