Taniborbactam

CAT: 0804-HY-109124-05Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-109124-05Size:50 mg

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Description

Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].

CAS Number

1613267-49-4

Product Name Alternative

VNRX-5133

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Taniborbactam.html

Purity

98.45

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O

Molecular Formula

C19H28BN3O5

Molecular Weight

389.25

References & Citations

[1]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62 (18) :8544-8556.|[2]Liu B , et al. Discovery of Taniborbactam (VNRX-5133) : A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

Antimicrob Agents Chemother. 2023 Jul 18;67 (7) :e0033923.|Antimicrob Agents Chemother. 2024 Feb 7;68 (2) :e0133223.|Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Engineering. 2024 Apr 12.|FEMS Microbiol Lett. 2025 Jan 10:372:fnaf044.|Int J Antimicrob Agents. 2024 Jan;63 (1) :107030.|Int J Antimicrob Agents. 2025 Jun 20:107557.|J Antimicrob Chemother. 2023 May 3;78 (5) :1191-1194.|J Glob Antimicrob Resist. 2025 Jul 7:44:265-271.|Sci Rep. 2025 Sep 29;15 (1) :33616.|Antimicrob Agents Chemother. 2022 Feb 15;66 (2) :e0167621.|Antimicrob Agents Chemother. 2025 Jun 9:e0029725.

Chemical Information

Taniborbactam

See also: Taniborbactam (annotation moved to).

CAS Number	1613267-49-4
PubChem CID	76902493
IUPAC Name	(3R)-3-[[2-[4-(2-aminoethylamino)cyclohexyl]acetyl]amino]-2-hydroxy-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid
Molecular Formula	C19H28BN3O5
Molecular Weight	389.3
Topological Polar Surface Area	134
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	28
Formal Charge	0
Complexity	544

SMILES

B1([C@H](CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC3CCC(CC3)NCCN)O

InChI

InChI=1S/C19H28BN3O5/c21-8-9-22-14-6-4-12(5-7-14)10-17(24)23-16-11-13-2-1-3-15(19(25)26)18(13)28-20(16)27/h1-3,12,14,16,22,27H,4-11,21H2,(H,23,24)(H,25,26)/t12?,14?,16-/m0/s1

InChIKey

PFZUWUXKQPRWAL-PXCJXSSVSA-N

Chemical Structure

2D Structure

CAS: 1613267-49-4

CID: 76902493

Formula: C19H28BN3O5

MW: 389.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	389.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	389.2122012
Monoisotopic Mass	389.2122012
Topological Polar Surface Area	134 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	544
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M12338-01	Taniborbactam
A20232-1	Taniborbactam 1mg
MBS5767696-01	Taniborbactam hydrochloride
A20232-5	Taniborbactam 5mg
A20232-10	Taniborbactam 10mg
GTR19213359	Taniborbactam (VNRX-5133)

Taniborbactam

Chemical Information

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