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Taniborbactam

CAT: 0804-HY-109124-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109124-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].
CAS Number
1613267-49-4
Product Name Alternative
VNRX-5133
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Taniborbactam.html
Purity
98.45
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O
Molecular Formula
C19H28BN3O5
Molecular Weight
389.25
References & Citations
[1]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62 (18) :8544-8556.|[2]Liu B , et al. Discovery of Taniborbactam (VNRX-5133) : A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Citation 01
Antimicrob Agents Chemother. 2023 Jul 18;67 (7) :e0033923.|Antimicrob Agents Chemother. 2024 Feb 7;68 (2) :e0133223.|Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Engineering. 2024 Apr 12.|FEMS Microbiol Lett. 2025 Jan 10:372:fnaf044.|Int J Antimicrob Agents. 2024 Jan;63 (1) :107030.|Int J Antimicrob Agents. 2025 Jun 20:107557.|J Antimicrob Chemother. 2023 May 3;78 (5) :1191-1194.|J Glob Antimicrob Resist. 2025 Jul 7:44:265-271.|Sci Rep. 2025 Sep 29;15 (1) :33616.|Antimicrob Agents Chemother. 2022 Feb 15;66 (2) :e0167621.|Antimicrob Agents Chemother. 2025 Jun 9:e0029725.

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