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Risdiplam-d4

CAT: 0804-HY-109101SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109101SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Risdiplam-d4 is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1].
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.89
Solubility
10 mM in DMSO|DMSO : 1.7mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(C2=NN3C(C(C)=C2)=NC(C)=C3)N=C4N1C=C(N(C5([2H])[2H])CC([2H])([2H])NC65CC6)C=C4
Molecular Formula
C22H19D4N7O
Molecular Weight
405.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Poirier A, et al. Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. Pharmacol Res Perspect. 2018 Nov 29;6 (6) :e00447.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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