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MRS2279

CAT: 0804-HY-108657Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108657Size:1 mg
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Description
MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05) [1][2][3].
CAS Number
[367909-40-8]
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrs2279.html
Solubility
10 mM in DMSO
Smiles
O=[P](O)(O)OC[C@]1([C@H]2O[P](O)(O)=O)[C@]([C@](N3C4=NC(Cl)=NC(NC)=C4N=C3)([H])C2)([H])C1
Molecular Formula
C13H18ClN5O8P2
Molecular Weight
469.71
References & Citations
[1]Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y (1) receptor ligands. J Med Chem. 2000;43 (5) :829-842.|[2]Boyer JL, et al, Ravi RG, Jacobson KA, Harden TK. 2-Chloro N (6) -methyl- (N) -methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y (1) receptor antagonist. Br J Pharmacol. 2002;135 (8) :2004-2010.|[3]Wei W, et al. Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release. Bioengineered. 2022 Feb;13 (2) :2346-2359.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y1 Receptor

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