Y-27152

• Description :

  Y-27152, a proagent of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2].

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/y-27152.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(N([C@H]1[C@H](O)C(C)(C)OC2=CC=C(C#N)C=C12)OCC3=CC=CC=C3)=O

• Molecular Formula :

  C21H22N2O4

• Molecular Weight :

  366.41

• References & Citations :

  [1]Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261 (2) :730-6.|[2]Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323 (2-3) :197-204.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [127408-30-4]