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Y-27152

CAT: 0804-HY-108582Size: 1 EachDry Ice: NoHazardous: No
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Description
Y-27152, a proagent of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2].
CAS Number
127408-30-4
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/y-27152.html
Solubility
10 mM in DMSO
Smiles
CC(N([C@H]1[C@H](O)C(C)(C)OC2=CC=C(C#N)C=C12)OCC3=CC=CC=C3)=O
Molecular Formula
C21H22N2O4
Molecular Weight
366.41
References & Citations
[1]Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261 (2) :730-6.|[2]Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323 (2-3) :197-204.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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