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(E) -FeCP-oxindole

CAT: 0804-HY-108444ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108444ASize:1 mg
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Description
(Z) -FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z) -FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z) -FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
CAS Number
884338-18-5
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-fecp-oxindole.html
Solubility
10 mM in DMSO
Smiles
[][Fe][].O=C1NC2=C(C=CC=C2)/C1=C\c3cccc3.c4cccc4
Molecular Formula
C19H15FeNO
Molecular Weight
329.17
References & Citations
[1]John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3 (6) :600-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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