Pemetrexed-d5

• Description:

  Pemetrexed-d5 is the deuterium labeled Pemetrexed[1]. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[2].

• Product Name Alternative:

  LY231514-d5

• UNSPSC:

  12352005

• Target:

  Antifolate; Autophagy

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C([2H])([2H])C([2H])([2H])[C@](C(O)=O)([2H])NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O

• Molecular Formula:

  C20H16D5N5O6

• Molecular Weight:

  432.44

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[3]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1129408-57-6