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Pemetrexed (disodium) -13C5

CAT: 0804-HY-W769288Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W769288Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pemetrexed disodium-13C5 (LY231514 disodium-13C5) is the 13C-labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].
Product Name Alternative
LY231514 (disodium) -13C5
UNSPSC
12352005
Target
Antifolate; Apoptosis; Autophagy; Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N=C(NC2=C1C(CCC3=CC=C(C=C3)C(N[13C@@H]([13CH2][13CH2][13C](O[Na])=O)[13C](O[Na])=O)=O)=CN2)N
Molecular Formula
C15 13C5H19N5Na2O6
Molecular Weight
476.34
References & Citations
[1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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