Eplivanserin

• Description :

  Eplivanserin (SR-46349) is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin displays >20-fold selectivity more selective for 5-HT2A than 5-HT2B and 5-HT2C[1][2].

• Product Name Alternative :

  SR-46349

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H410

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Eplivanserin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC=C(/C=C/C(C2=CC=CC=C2F)=N/OCCN(C)C)C=C1

• Molecular Formula :

  C19H21FN2O2

• Molecular Weight :

  328.39

• Precautions :

  P264-P270-P273-P330-P391-P501

• References & Citations :

  [1]Rinaldi-Carmona M, et al. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. J Pharmacol Exp Ther. 1992 Aug;262 (2) :759-68.|[2]Malgorzata Filip, et al. Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther. 2004 Sep;310 (3) :1246-54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  5-HT2 Receptor; α-1 microglobulin

• CAS Number :

  [130579-75-8]