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JNJ-10181457

CAT: 0804-HY-107562ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107562ASize:1 Each
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Description
JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1]. JNJ-10181457 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
544707-19-9
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-10181457.html
Solubility
10 mM in DMSO
Smiles
C1(C#CCCN2CCCCC2)=CC(CN3CCOCC3)=CC=C1
Molecular Formula
C20H28N2O
Molecular Weight
312.45
References & Citations
[1]Mónica García, et al. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118 (2) :113-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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