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Oxythiamine (chloride)

CAT: 0804-HY-107430BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107430BSize:1 Each
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Description
Oxythiamine (Hydroxythiamine) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK) . Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].
CAS Number
582-36-5
Product Name Alternative
Hydroxythiamine (chloride)
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oxythiamine-chloride.html
Solubility
10 mM in DMSO
Smiles
CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O.[Cl-]
Molecular Formula
C12H16ClN3O2S
Molecular Weight
301.79
References & Citations
[1]Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18.|[2]Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16 (3) :633-641.|[3]Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456 (1) :113-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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