Oxythiamine

• Description:

  Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK) . Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].

• Product Name Alternative:

  Hydroxythiamin

• UNSPSC:

  12352005

• Target:

  Apoptosis; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Oxythiamine.html

• Purity:

  98.17

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O

• Molecular Formula:

  C12H16N3O2S

• Molecular Weight:

  266.34

• References & Citations:

  [1]Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. |[2]Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456 (1) :113-8. |[3]Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16 (3) :633-641. |[4]Yang CM, et al. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis. 2010 May;27 (5) :341-9.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  136-16-3