7β-Hydroxy-epi-androsterone

• Description :

  7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].

• Product Name Alternative :

  7β-Hydroxy-EpiA

• UNSPSC :

  12352211

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/7β-hydroxy-epi-androsterone.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@]3([H])[C@]([C@@H](O)C[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3

• Molecular Formula :

  C19H30O3

• Molecular Weight :

  306.44

• References & Citations :

  [1]Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30. |[2]Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77 (5) :542-51.|[3]Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110 (3-5) :255-62. |[4]Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15 (2) :262-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  ERβ

• CAS Number :

  [25848-69-5]