7β-Hydroxy-epi-androsterone

• UNSPSC Description:

  7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/7β-hydroxy-epi-androsterone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@]3([H])[C@]([C@@H](O)C[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3

• Molecular Weight:

  306.44

• References & Citations:

  [1]Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30. |[2]Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77(5):542-51.|[3]Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):255-62. |[4]Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  25848-69-5