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Metapramine

CAT: 0804-HY-107031-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107031-01Size:25 mg
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Description
Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1][2][3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].
CAS Number
21730-16-5
Product Name Alternative
19560 RP
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/metapramine.html
Solubility
10 mM in DMSO
Smiles
CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1
Molecular Formula
C16H18N2
Molecular Weight
238.33
References & Citations
[1]M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2 (3) :219-23.|[2]H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180 (1) :43-8.|[3]J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14 (2) :261-70.|[4]A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35 (12) :1703-7.|[5]Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31 (3) :391-400. doi: 10.1016/0304-3959 (87) 90167-9.|[6]M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2 (3) :219-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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