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Eberconazole

CAT: 0804-HY-106542Size: 1 EachDry Ice: NoHazardous: No
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Description
Eberconazole is a dichlorinated imidazole derivative with antifungal activity. Eberconazole is more effective than Clotrimazole , Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole has potential for the study of dermatophytosis[1][2].
CAS Number
128326-82-9
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/eberconazole.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(CCC2=C(C3N4C=NC=C4)C=CC=C2)=C3C(Cl)=C1
Molecular Formula
C18H14Cl2N2
Molecular Weight
329.22
References & Citations
[1]Fernández-Torres B, et al. In vitro activities of the new antifungal drug eberconazole and three other topical agents against 200 strains of dermatophytes. J Clin Microbiol. 2003;41 (11) :5209-5211. |[2]Moodahadu L S, et al. Preclinical pharmacological profile of Eberconazole: A review and update[J]. Muller Journal of Medical Sciences and Research, 2014, 5 (2) : 159-165.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Eberconazole

1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole is a member of the class of dibenzannulenes that is 10,11-dihydrodibenzo[a,d][7]annulene carrying two chloro substituents at positions 2 and 4 as well as an imidazol-1-yl substituent at position 5. It is a member of imidazoles, a dibenzannulene and an organochlorine compound. It derives from a hydride of a dibenzo[a,d][7]annulene.

CAS Number128326-82-9
PubChem CID72051
IUPAC Name1-(4,6-dichloro-2-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaenyl)imidazole
Molecular FormulaC18H14Cl2N2
Molecular Weight329.2
XLogP4.9
Topological Polar Surface Area17.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity391
SMILES
C1CC2=C(C(C3=CC=CC=C31)N4C=CN=C4)C(=CC(=C2)Cl)Cl
InChI
InChI=1S/C18H14Cl2N2/c19-14-9-13-6-5-12-3-1-2-4-15(12)18(17(13)16(20)10-14)22-8-7-21-11-22/h1-4,7-11,18H,5-6H2
InChIKey
MPTJIDOGFUQSQH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Eberconazole
CAS: 128326-82-9
CID: 72051
Formula: C18H14Cl2N2
MW: 329.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight329.2
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass328.0534038
Monoisotopic Mass328.0534038
Topological Polar Surface Area17.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity391
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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