ILS-920

CAT: 0804-HY-106345Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-106345Size:1 Each

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Description

ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC) . ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12[1].

CAS Number

892494-07-4

UNSPSC

12352005

Target

Calcium Channel; FKBP

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ils-920.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@H](OC)C[C@H](C[C@@H](C)[C@@H](OC([C@@H]2CCCCN2C(C([C@@]3(O)[C@H](C)CC[C@@H](C[C@H](OC)/C(C)=C/[C@@H]4ON(C5=CC=CC=C5)[C@H]([C@H](C[C@H]6C)C)CC4)O3)=O)=O)=O)CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C6=O)=O)CC1

Molecular Formula

C57H86N2O14

Molecular Weight

1023.30

References & Citations

[1]Ruan B, et al. Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008 Jan 8;105 (1) :33-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

FKBP52; L-type calcium channel

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HY-106394	TP-9201
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T13734	ILS-920
110052	Hsp-920
A3239-100	B-HT 920
278973-01	B-HT 920 dihydrochloridetalipexole
MBS386716-01	B-HT 920 2HCl
MPH02016	hsa-miR-920 Primers
CMH0680-01	Hsa-miR-920 miRNA Mimic
A11341-500	B-HT 920 2HCl 500mg
TRC-B371000-5MG	B-HT 920 Dihydrochloride Talipexole
GTR19320817-01	Hsa-miR-920 miRNA Inhibitor

ILS-920

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