Echinomycin

• Description :

  Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2].

• CAS Number :

  [512-64-1]

• Product Name Alternative :

  Quinomycin A; NSC-13502

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331, H361

• Target :

  Antibiotic; Bacterial; HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/echinomycin.html

• Purity :

  98.57

• Solubility :

  DMSO : 5.3 mg/mL (ultrasonic)

• Smiles :

  [H]C1=NC2=C(N=C1C(N[C@H](COC([C@H](C(C)C)N(C)C([C@H]3N4C)=O)=O)C(N[C@@H](C)C(N(C)[C@@H]([C@@H](SC)SC3)C(N(C)[C@@H](C(C)C)C(OC[C@@H](NC(C5=NC6=C(C=CC=C6)N=C5[H])=O)C(N[C@@H](C)C4=O)=O)=O)=O)=O)=O)=O)C=CC=C2

• Molecular Formula :

  C51H64N12O12S2

• Molecular Weight :

  1101.26

• Precautions :

  H301, H311, H331, H361

• References & Citations :

  [1]Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65 (19) :9047-55.|[2]Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8 (4) :399-411.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported