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Furegrelate

CAT: 0804-HY-106080Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106080Size:1 Each
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Description
Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent[1][2].
CAS Number
85666-24-6
Product Name Alternative
U-63557A (free acid)
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/furegrelate.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O
Molecular Formula
C15H11NO3
Molecular Weight
253.25
References & Citations
[1]Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5- (3'-pyridinylmethyl) benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26 (2) :325-42. |[2]Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2 (2) :193-200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T11339L-01Furegrelate
M26221-01Furegrelate sodium
C5692-10Furegrelate (sodium salt)
sc-200705Furegrelate Sodium (U-63557A)

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