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Tropatepine

CAT: 0804-HY-105710-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105710-01Size:5 mg
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Description
Tropatepine is an orally active, anticholinergic muscarinic antagonist and can be used as an antiparkinsonian agent[1]. Tropatepine is used to combat against extrapyramidal syndrome induced by neuroleptic agents[2].
CAS Number
27574-24-9
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tropatepine.html
Purity
99.63
Solubility
10 mM in DMSO
Smiles
CN1[C@@H]2C/C(C[C@H]1CC2)=C3C4=CC=CC=C4SCC5=CC=CC=C\35
Molecular Formula
C22H23NS
Molecular Weight
333.49
References & Citations
[1]P Celsis, et al. Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1989 Jul;52 (7) :917-8.|[2]P Arnoux, et al. Simultaneous determination of tropatepine and its major metabolites by high-performance liquid chromatographic-mass spectrometric identification. Application to metabolic and kinetic studies. J Chromatogr. 1986 Aug 22;381 (1) :75-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Tropatepine

Tropatepine has been used in France for its antiparkinsons activities.

CAS Number27574-24-9
PubChem CID3034047
IUPAC Name(1R,5S)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-8-methyl-8-azabicyclo[3.2.1]octane
Molecular FormulaC22H23NS
Molecular Weight333.5
XLogP4.8
Topological Polar Surface Area28.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count24
Formal Charge0
Complexity496
SMILES
CN1[C@@H]2CC[C@H]1CC(=C3C4=CC=CC=C4CSC5=CC=CC=C53)C2
InChI
InChI=1S/C22H23NS/c1-23-17-10-11-18(23)13-16(12-17)22-19-7-3-2-6-15(19)14-24-21-9-5-4-8-20(21)22/h2-9,17-18H,10-14H2,1H3/t17-,18+
InChIKey
JOQKFRLFXDPXHX-HDICACEKSA-N
Chemical Structure
2D Structure
2D structure of Tropatepine
CAS: 27574-24-9
CID: 3034047
Formula: C22H23NS
MW: 333.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight333.5
XLogP34.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass333.15512091
Monoisotopic Mass333.15512091
Topological Polar Surface Area28.5 Ų
Heavy Atom Count24
Formal Charge0
Complexity496
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
AR-T00899-01Tropatepine
AR-T00897-01Tropatepine Sulfoxide
TRC-T386851-100MGTropatepine-¹³CD₃
CS-T-103795Tropatepine-Â1Â3CD₃
AR-T00898-01Tropatepine-13C D3
AR-T06084-01Tropatepine Impurity 1 (Mixture of Diastereomers)

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