FR 113680

• Description :

  FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1].

• UNSPSC :

  12352209

• Target :

  Neurokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/fr-113680.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN(CC1=CC=CC=C1)C([C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H]([C@H](O)C)NC(C)=O)=O)CC3=CN(C=O)C4=C3C=CC=C4)=O)=O

• Molecular Formula :

  C35H39N5O6

• Molecular Weight :

  625.71

• References & Citations :

  [1]Morimoto H, et al. FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106 (1) :123-6.|[2]Morimoto H, et al. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224 (1) :1-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [126088-92-4]