Calphostin C

• UNSPSC Description:

  Calphostin C is a potent and specific inhibitor of protein kinase C. Calphostin C is an antitumor antibiotic. Calphostin C has 1000 times more inhibitory to protein kinase C with an IC50 of 0.05 μM than other protein kinases. Calphostin C induces apoptosis in some tumor cell lines. Calphostin C has potent cytotoxic activity and antitumor activity[1].

• Target Antigen:

  Antibiotic; Apoptosis; PKC

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Epigenetics;TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/calphostin-c.html

• Purity:

  99.0

• Solubility:

  DMSO : 1 mg/mL (ultrasonic;warming)

• Smiles:

  O=C(O[C@@H](CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(C[C@@H](C)OC(C6=CC=CC=C6)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O

• Molecular Weight:

  790.76

• References & Citations:

  [1]Kobayashi E, et al. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1989;159(2):548-553. |[2]Kobayashi E, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989;42(10):1470-1474.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  121263-19-2