Calphostin C

• Description:

  Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications[1][2][3].

• Product Name Alternative:

  UCN-1028C

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Antibiotic; Apoptosis; PKC

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/calphostin-c.html

• Purity:

  99.9

• Solubility:

  DMSO : 1 mg/mL (ultrasonic; warming)

• Smiles:

  O=C(O[C@@H](CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(C[C@@H](C)OC(C6=CC=CC=C6)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O

• Molecular Formula:

  C44H38O14

• Molecular Weight:

  790.76

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Kobayashi E, et al. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1989;159 (2) :548-553.|[2]Chen CL, et al. Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity. Pharm Res. 1999 Jul;16 (7) :1003-9.|[3]Hermenegildo C, et al. Sustained recovery of Na (+) -K (+) -ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC. Diabetes. 1993 Feb;42 (2) :257-62.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  121263-19-2