CEP-9722

• Description:

  CEP-9722, the proagent of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].

• UNSPSC:

  12352005

• Target:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cep-9722.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1CN2CCN (C) CC2) C3=C4C5=C (OC) C=CC=C5NC4=C6C (CCC6) =C3C1=O

• Molecular Formula:

  C24H26N4O3

• Molecular Weight:

  418.49

• References & Citations:

  [1]Weiguo Jian, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014 Sep;25 (8) :878-86.|[2]Ruth Plummer, et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Aug;74 (2) :257-65.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  PARP1; PARP2

• CAS Number:

  916574-83-9