CEP-9722

• Description :

  CEP-9722, the proagent of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].

• UNSPSC :

  12352005

• Target :

  PARP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cep-9722.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1CN2CCN(C)CC2)C3=C4C5=C(OC)C=CC=C5NC4=C6C(CCC6)=C3C1=O

• Molecular Formula :

  C24H26N4O3

• Molecular Weight :

  418.49

• References & Citations :

  [1]Weiguo Jian, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014 Sep;25 (8) :878-86.|[2]Ruth Plummer, et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Aug;74 (2) :257-65.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  PARP1; PARP2

• CAS Number :

  [916574-83-9]