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Zoniporide (hydrochloride)

CAT: 0804-HY-105064BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105064BSize:1 Each
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Description
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1) . Zoniporide hydrochloride inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM) [1][2].
CAS Number
241800-97-5
Product Name Alternative
CP-597396 (hydrochloride)
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zoniporide-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl
Molecular Formula
C17H17ClN6O
Molecular Weight
356.81
References & Citations
[1]Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1) . Cardiovasc Drug Rev. 2003 Spring;21 (1) :17-32.|[2]Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11 (6) :803-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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