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Zoniporide

CAT: 0804-HY-105064-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-105064-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM) . Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].
CAS Number
[241800-98-6]
Product Name Alternative
CP-597396
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zoniporide.html
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O
Molecular Formula
C17H16N6O
Molecular Weight
320.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Marala, et al. "Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1." European journal of pharmacology 451.1 (2002) : 37-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Carbohydr Polym. 2023 Jan 1:299:120179.|J Biol Chem. 2021 Oct;297 (4) :101166.

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