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A-77636 (hydrochloride)

CAT: 0804-HY-103416Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103416Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].
CAS Number
145307-34-2
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-77636-hydrochloride.html
Purity
98.0
Solubility
DMSO : 33 mg/mL (ultrasonic)
Smiles
[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3
Molecular Formula
C20H28ClNO3
Molecular Weight
365.89
References & Citations
[1]Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229 (2-3) :203-209.|[2]Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna) . 2002;109 (2) :123-140.|[3]Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532 (3) :253-257.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor

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