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SKF 83959 (hydrobromide)

CAT: 0804-HY-103412Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103412Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKF83959 hydrobromide is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 hydrobromide Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ) -1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression[1][2][3][4].
CAS Number
67287-95-0
UNSPSC
12352005
Target
Dopamine Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf-83959-hydrobromide.html
Purity
99.86
Solubility
DMF : 20 mg/mL (ultrasonic; warming) |DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl.[H]Br
Molecular Formula
C18H21BrClNO2
Molecular Weight
398.72
References & Citations
[1]Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41 (3) :427-434.|[2]Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85 (2) :378-386.|[3]Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474 (2-3) :137-140.|[4]Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83 (3) :577-586.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor

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