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Proglumide (Standard)

CAT: 0804-HY-B1330R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1330R-01Size:5 mg
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Description
Proglumide (Standard) is the analytical standard of Proglumide. This product is intended for research and analytical applications. Proglumide is a nonpeptide and orally active cholecystokinin (CCK) -A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS) . Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities[1][2][3][4][5].
CAS Number
[6620-60-6]
UNSPSC
12352100
Target
Cholecystokinin Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology; Neurological Disease
Smiles
O=C(O)CCC(NC(C1=CC=CC=C1)=O)C(N(CCC)CCC)=O
Molecular Formula
C18H26N2O4
Molecular Weight
334.41
References & Citations
[1]Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus. Oxid Med Cell Longev. 2014;2014:630509.|[2]Iwamoto Y, et al. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol Jpn. 1984 Feb;19 (1) :53-8.|[3]González-Puga C, et al. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. J Pineal Res. 2005 Oct;39 (3) :243-50.|[4]Bunney BS, et al. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system. Ann N Y Acad Sci. 1985;448:345-51.|[5]Tariq M, et al. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. J Pharmacol Exp Ther. 1987 May;241 (2) :602-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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