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ZJ43

CAT: 0804-HY-103344Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103344Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].
CAS Number
723331-20-2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zj43.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(O)=O)CCC(O)=O)N[C@H](C(O)=O)CC(C)C
Molecular Formula
C12H20N2O7
Molecular Weight
304.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Olszewski RT, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem. 2004 May;89 (4) :876-85.|[2]Yamamoto T, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci. 2004 Jul;20 (2) :483-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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