Products for Research Use Only
RegisterLogin

ZJ43

CAT: 0498-bs-82721C-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-82721C-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
ZJ43 is potent inhibitor of glutamate carboxypeptidases II (Ki = 0.8 nM) and III (Ki = 23 nM) .1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It potently (IC50 = 2.4 nM) inhibited the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG) resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia.2,3 ZJ43 has also shown efficacy in other inflammatory pain models.4,5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-103344ZJ43
TBI3904-25MGZJ43, Potent inhibitor of glutamate carboxypeptidases II and III

Popular Products